Effects of curcumin-coated nanomicelles on cerebral ischemia injury in rats by regulating lncRNA GAS5 and NF-κB signalling pathways

This work aimed to investigate the effects of curcumin (Cur) encapsulated in triblock copolymer nanomicelles on lncRNA GAS5 expression and NF-κB signalling pathway ischemic stroke rats. Using polycaprolactone (PCL), polyethylene (mPEG), polyglutamic acid (PLG), Cur as raw materials, Cur-PLG-mPEG-PCL nanoparticles were prepared. Its morphology, particle size, Zeta potential analyzed. Then seventy-two SD rats randomly divided into control (Ctrl) group, model + blank (M BNM) +80 mg/mL C) +40 Cur-nanomicelles CNM (40 mg/mL)) nanomicelle (80 group. The results showed that mean size was (148.27 ± 27.44) nm, (−1.97 0.21) mV. evaluation time intelligent optimization algorithm based Single Shot MultiBox Detector (SSD) significantly shortened, average EEG power spectrum cerebral pawns lower than group at θ, α, β, γ bands for 4h (p < 0.01). These indicate computer can be used evaluate behaviour rats, reflect changes cortical function, improve neurological function degree brain injury.